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A fluorinated pyridine building block

Used for the synthesis of APIs in cancer treatment and ligands for chemical reactions

Specifications | MSDS | Literature and Reviews

4-Amino-2-(trifluoromethyl)pyridine (CAS number -98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesising pyridine-based ligands to stabilise hypervalent iodine which is applied in a wide range of synthetic transformations.

4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.

Multiple functional groups

For facile synthesis

Fluorinated building block

Link to huimeng

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number -98-2 Chemical Formula C6H5F3N2 Full Name 2-(Trifluoromethyl)-4-pyridinamine Molecular Weight 162.11 g/mol Synonyms 2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands

Chemical Structure

4-Amino-2-(trifluoromethyl)pyridine chemical structure, CAS -98-2

Product Details

Purity 98% Melting Point Tm = 58 °C &#; 62 °C Appearance White crystals

MSDS Documentation

4-Amino-2-(trifluoromethyl)pyridine MSDS Sheet

Literature and Reviews

1. Multiparameter lead optimization to give an oral checkpoint kinase 1 (CHK1) inhibitor clinical candidate: (R)&#;5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT), J. Osborne et al., J. Med. Chem., 59, &#;(); DOI: 10./acs.jmedchem.5b.
2. Greener and efficient synthesis of some novel substituted azitidinones with 4-amino pyridine via heterogenous catalyst, K. Avasthi et al., J. Appl. Chem., 3(5), &#;(); ISSN: -.
3. Preparation of (bis)cationic nitrogen-ligated I(III) reagents: synthesis of [(pyridine)2IPh](OTF)2 and [(4-CF3-pyridine)2IPh](OTF)2, B. Hoblos et al., Organic Synth., 98, 391&#;406(); DOI: 10./orgsyn.098..

4. Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex, J. Vasta et al., Cell Chem. Biol., 30, 1&#;12(); DOI: 10./j.chembiol..07.019.

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